Diagnostic criteria for acute liver failure due to Wilson disease

Table 2 Comparison of clinical findings between the groups

	FWD	ALF	P
Age (yr)	20.1 ± 11.7	44.8 ± 20.6	0.016
MELD score	27.6 ± 9.5	20.3 ± 7.0	0.108
HE (grade 1-4)	1.4 ± 0.5	2.13 ± 1.0	0.122
Serum ALT (U/L)	53 ± 43	1982 ± 938	< 0.0001
Serum AST (U/L)	87 ± 44	2756 ± 2941	0.037
AST-ALT ratio	2.3 ± 1.5	1.5 ± 1.2	0.266
Serum AP (U/L)	128 ± 89	142 ± 66	0.749
Serum LDH (U/L)	535 ± 638	1567 ± 2707	0.382
Serum bilirubin (mg/dL)	23 ± 19	15 ± 13	0.372
AP-bilirubin ratio	9.3 ± 8.9	32.5 ± 59.0	0.363
INR	2.1 ± 0.4	2.1 ± 0.6	0.816
Albumin (g/L)	29.8 ± 4.7	32.0 ± 3.8	0.379
CHE (kU/L)	1.8 ± 1.2	4.3 ± 1.2	0.005
Hemoglobin (g/L)	7.0 ± 2.2	12.6 ± 1.8	< 0.0001
Serum copper (μmol/L)	28.1 ± 29.4	17.8 ± 2.5	0.376
Serum ceruloplasmin (g/L)	0.12 ± 0.08	0.19 ± 0.03	0.07
Urinary copper (μmol/24 h)	93.4 ± 144.0	3.5 ± 1.8	0.001

FWD: acute liver failure secondary to WD; ALF: acute liver failure; HE: hepatic encephalopathy; ALT: alanine aminotransferase; AP: alkaline phosphatase; INR: international normalized ratio; CHE: choline esterase.