Risk factors for Barrett’s oesophagus and oesophageal adenocarcinoma: Results from the FINBAR study

Table 5 Smoking in controls, Barrett’s oesophagus and oesophageal adenocarcinoma patients

	Controls	Barrett's oesophagus			Oesophageal adenocarcinoma
	No.	No.	Adjusted1OR (95% CI)	Further adjusted for GOROR (95% CI)	No.	Adjusted1OR (95% CI)	Further adjusted for GOROR (95% CI)
Smoking status (5 yr prior to interview)
Never2	102	87	1.00	1.00	46	1.00	1.00
Ex-smoker	107	85	0.97 (0.63 to 1.49)	0.86 (0.53 to 1.40)	99	1.85 (1.15 to 2.97)	1.72 (1.06 to 2.81)
Current smoker	45	50	1.27 (0.74 to 2.17)	1.41 (0.77 to 2.58)	77	4.64 (2.64 to 8.17)	4.84 (2.72 to 8.61)
No. of cigarettes smoked per day
Never2	102	87	1.00	1.00	46	1.00	1.00
< 15	54	41	0.94 (0.57-1.57)	0.98 (0.55 to 1.75)	44	1.85 (1.07-3.20)	1.87 (1.06 to 3.28)
15-20	51	41	0.98 (0.58-1.65)	0.94 (0.52 to 1.69)	67	3.14 (1.83-5.37)	3.05 (1.76 to 5.30)
> 20	49	53	1.32 (0.78-2.22)	1.16 (0.65 to 2.09)	66	2.92 (1.68-5.10)	2.72 (1.54 to 4.80)
Duration of smoking (yr)
Never2	102	87	1.00	1.00	46	1.00	1.00
< 20	47	28	0.72 (0.41 to 1.28)	0.72 (0.38 to 1.38)	38	1.92 (1.07 to 3.44)	1.91 (1.05 to 3.48)
20-35	55	57	1.21 (0.74 to 1.98)	1.09 (0.62 to 1.90)	54	2.08 (1.21 to 3.58)	1.94 (1.11 to 3.38)
> 35	53	51	1.18 (0.70 to 1.98)	1.18 (0.66 to 2.11)	85	3.74 (2.18 to 6.40)	3.71 (2.14 to 6.42)
Years since quitting smoking
Never2	102	87	1.00	1.00	46	1.00	1.00
< 26	27	29	1.27 (0.74 to 2.19)	1.42 (0.78 to 2.60)	36	4.72 (2.68 to 8.31)	4.89 (2.74 to 8.71)
26-41	40	32	1.26 (0.68 to 2.33)	1.11 (0.56 to 2.20)	29	2.68 (1.42 to 5.07)	2.51 (1.30 to 4.83)
> 41	40	24	1.02 (0.58 to 1.81)	0.89 (0.47 to 1.70)	34	1.52 (0.82 to 2.85)	1.40 (0.74 to 2.66)
Pack years of smoking
Never2	102	87	1.00	1.00	46	1.00	1.00
< 15	48	36	0.92 (0.54 to 1.57)	0.94 (0.51 to 1.72)	30	1.39 (0.76 to 2.55)	1.39 (0.75 to 2.58)
15-40	55	47	1.01 (0.61 to 1.67)	0.92 (0.52 to 1.63)	68	2.95 (1.74 to 5.00)	2.84 (1.66 to 4.86)
> 40	51	52	1.28 (0.76 to 2.17)	1.23 (0.68 to 2.21)	79	3.48 (2.01 to 6.02)	3.34 (1.91 to 5.83)
Cigar
Never	234	204	1.00	1.00	194	1.00	1.00
Ever	22	18	0.84 (0.41 to 1.71)3	0.73 (0.33 to 1.61)3	29	1.30 (0.67 to 2.53)3	1.22 (0.61 to 2.43)3
Pipe
Never	233	194	1.00	1.00	182	1.00	1.00
Ever	23	28	1.68 (0.88 to 3.20)3	1.31 (0.64 to 2.68)3	41	1.64 (0.88 to 3.06)3	1.45 (0.77 to 2.75)3

GOR: gastro-oesophageal reflux; OR: odds ratio; CI: confidence interval.

¹Adjusted for sex, age at interview date, body mass index 5 yr prior to the interview date, alcohol intake (grams), years of full-time education and job type (manual, non-manual).

²Never smoked, smoked less than 100 cigarettes in lifetime or smoked less than 1 cigarette per day for 6 mo in their lifetime

³Adjusted for use of other tobacco products e.g. cigarettes, pipe or cigar respectively.