Th immune response induced by H pylori vaccine with chitosan as adjuvant and its relation to immune protection

Table 6 Levels of anti-HpIgG2a, IgG1 and ratio of IgG2a/IgG1 in serum after challenge (mean ± SD)

Groups	N	IgG2a	IgG1	IgG2a/IgG1
(1) Control	10	4.44 ± 2.09	2.77 ± 1.18	2.13 ± 1.24
(2) Chi-solution	11	6.28 ± 3.62	3.96 ± 2.32	1.64 ± 0.85
(3) Chi-particles	10	5.56 ± 2.27	4.57 ± 2.09	1.43 ± 0.37gh
(4) Hp antigen	9	9.21 ± 6.80a	6.43 ± 4.88a	2.356 ± 1
(5) Hp antigen + CT	10	11.22 ± 5.52a	7.71 ± 5.11de	2.19 ± 0.86
(6) Hp antigen + chi-solution	10	11.48 ± 5.55a	9.04 ± 5.35b	1.06 ± 0.4f
(7) Hp antigen + chi-particles	10	16.13 ± 10.20b	8.02 ± 5.29cd	1 ± 0.37f
		F = 4.572	F = 10.308	F = 3.780
		P < 0.001	P < 0.001	P < 0.001

^aP < 0.05 vs (1) group;

^bP < 0.01 vs (1)-(3) groups;

^cP < 0.05 vs (2) and (3) groups,

^dP < 0.01 vs (1) group;

^eP < 0.05 vs (2) group;

^fP < 0.01 vs (1), (4) and (5) groups;

^gP < 0.05 vs (5) group;

^hP < 0.01 vs (4) group.