Th immune response induced by H pylori vaccine with chitosan as adjuvant and its relation to immune protection

Table 4 Levels of IL-2, IFN-γ, IL-12, IL-10 and IL-4 in gastric mucosa before challenge (mean ± SD)

Groups	n	IL-2	IFN-γ	IL-12	IL-10	IL-4
(1) Control	5	19.9 ± 12.6	28.6 ± 10.2	118.9 ± 46.2	67.2 ± 32.5	4.19 ± 2.95
(2) Hp antigen	5	20.6 ± 3.5	33.6 ± 13.7	165.3 ± 47.4	104.3 ± 19.1	6.49 ± 2.61
(3) Hp antigen chi-solution	5	28.6 ± 9.3	58.5 ± 12.2b	283.5 ± 93.7cd	255.3 ± 131.8cd	14.70 ± 8.73a
(4) Hp antigen+ chi-particles	5	27.6 ± 13.9	59.8 ± 15.2b	283.4 ± 99.6cd	237.1 ± 98.3cd	14.48 ± 6.84a
		F = 0.739	F = 7.948	F = 6.083	F = 6.228	F = 4.189
		P = 0.544	P = 0.002	P = 0.006	P = 0.005	P = 0.023

^aP < 0.05 vs (1) and (2) groups;

^bP < 0.01 vs (1) and (2) groups;

^cP < 0.05 vs (2) group;

^dP < 0.01 vs (1) group; chi = chitoson.