The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection

Figure 5 Combination treatment with clevudine and WHsAg vaccine enhances and expands the pattern of cell-mediated immune responses to WHV antigens in chronic WHV carrier woodchucks. Changes in the PBMC responses to WHsAg, WHcAg, WHeAg, and WHxAg of chronic carriers in response to treatment with placebo (CLV-V-), vaccine (CLV-V+), drug (CLV+V-), and combination of drug and vaccine (CLV+V+) are shown. Horizontal bars denote the period of clevudine (CLV) administration for 32 wk. Arrowheads represent the 4 immunizations (V) using 50 μg doses of an alum-adsorbed, formalin-inactivated WHsAg vaccine at wk 32, 36, 40, and 48.