Smad3 knock-out mice as a useful model to study intestinal fibrogenesis

Figure 7 Immunohistochemical analysis (x 20) of α-SMA and collagens I-VII in colon from Smad3 null and wild-type mice. A similar localization of α-SMA antibody was found in miocytes of muscularis mucosae, muscle layer and vessels of both groups of animals. Staining of collagens I-VII in large intestine of Smad3 null and wild-type mice was localized mainly within connective tissue of submucosa and muscularis propria showing identical staining pattern between the two groups of mice.