Value of mink vomit model in study of anti-emetic drugs

doi:10.3748/wjg.v12.i8.1300

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Feb 28, 2006 (publication date) through Nov 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 28, 2006; 12(8): 1300-1302
Published online Feb 28, 2006. doi: 10.3748/wjg.v12.i8.1300

Table 2 Effects of ondansetron or metoclopramide on emesis induced by cisplatin or apomorphine in minks (mean±SD, n=6)

Emetogens	Dose (mg/kg)	Anti-emetics	Dose (mg/kg)	Latency (min)	Retching (n)	Emesis (n)
Cisplatin	7.5	NS		92.0 ± 21	91.5 ± 37	12 ±
Cisplatin	7.5	Ondansetron	2	143.8 ± 80	47.3 ± 41	5.3 ± 5^a
Apomorphine	1.6	NS		39.4 ± 36	28.5 ± 16	5.3 ± 1.9
Apomorphine	1.6	Metoclopramide	4	-a	1.3 ± 3^b	0.3 ± 0.8^d

^aP = 0.018, t = 2.93 vs vehicle-pretreated cisplatin group; ^bP = 0.0022, t’ = 4.08, ^dP = 0.003, t’ = 5.94 vs vehicle-pretreated apomorphine group; -a: only 1 monk had retching and vomiting.

Citation: Zhang F, Wang L, Yang ZH, Liu ZT, Yue W. Value of mink vomit model in study of anti-emetic drugs. World J Gastroenterol 2006; 12(8): 1300-1302
URL: https://www.wjgnet.com/1007-9327/full/v12/i8/1300.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i8.1300