Neutrophil depletion-but not prevention of Kupffer cell activation-decreases the severity of cerulein-induced acute pancreatitis

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Feb 28, 2006 (publication date) through Jul 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 28, 2006; 12(8): 1219-1224
Published online Feb 28, 2006. doi: 10.3748/wjg.v12.i8.1219

Table 1 Pancreatic injury in control (CONT) mice and mice treated with cerulein (CER)

	CONT	CER
Serum amylase (UI/L)	1582 [1236 - 1850]	19528 [16369 - 26457]	P < 0.0001
Pancreatic water content (% wet weight)	0.74 [0.71 – 0.76]	0.80 [0.78 - 0.83]	P < 0.0001
Pancreatic MPO activity (U/mg tissue dry weight)	322 [125 - 456]	2738 [1978 - 3245]	P = 0.0002
Pancreatic necrosis (%)	1.26 [0.5 – 2.3]	27.7 [24.5 – 35.0]	P = 0.0001

MPO = myeloperoxidase. n ≥ 5 in each group. Data in CER and CONT groups were compared with Mann-Whitney test.

Citation: Pastor CM, Vonlaufen A, Georgi F, Hadengue A, Morel P, Frossard JL. Neutrophil depletion-but not prevention of Kupffer cell activation-decreases the severity of cerulein-induced acute pancreatitis. World J Gastroenterol 2006; 12(8): 1219-1224
URL: https://www.wjgnet.com/1007-9327/full/v12/i8/1219.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i8.1219