Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett’s esophagus to adenocarcinoma

Figure 1 COX-2 staining in the sections from different stages of BE along with the sections from normal squamous and CLE nondetectable BE. A: Squamous epithelium (SE); B: Nondetectable BE in CLE (NB); C: Specialized intestinal metaplasia (SIM); D: Indeterminate/low-grade dysplasia (I/LGD); E: high-grade dysplasia (HGD); F: Esophageal adenocarcinoma (EAC). Strong COX-2 staining was detected in both NCP cells and ACP cells in the histological stages of SIM, I/LGD, HGD and EAC. A weak COX-2 staining was observed in the normal squamous epithelium.