Relationship between therapeutic efficacy of arterial infusion chemotherapy and expression of P-glycoprotein and p53 protein in advanced hepatocellular carcinoma

Table 3 Correlation between PGP or p53 protein positivity and therapeutic efficacy by anticancer drugs

Positivity	Anthracycline group (n = 20)				Response rate (%) (95%CI)	Non-anthracycline group (n = 21)				Response rate (%) (95%CI)
	CR	PR	NC	PD		CR	PR	NC	PD
PGP12
Non-positive group	2	6	3	0	72.7 (46.4-99.1)b	3	5	5	2	53.3 (28.1-78.6)
Positive group	0	0	4	5	0.0 (0.0-0.0)	0	1	3	2	16.7 (-13.2-46.5)
p5313
Non-positive group	2	4	2	4	50.0 (21.7-78.3)	3	6	6	2	52.9 (29.2-76.7)
Positive group	0	2	5	1	25.0 (-5.0-55.0)	0	0	2	2	0.0 (0.0-0.0)

^bP < 0.01 vs positive group (χ²).

¹Number of patients.

²Non-positive group: negative and weakly positive. Positive group: strongly positive.

³Non-positive group: negative. Positive group: weakly positive and strongly positive.