Involvement of mitochondrial Na+–Ca2+ exchange in intestinal pacemaking activity

Figure 2 The effect of CGP37157 in the pacemaking activity of the ICCs. CGP37157 was applied to examine its effect on the pacemaking activity of ICCs. A, B, and C: Under a current clamp (I = 0), CGP37157 inhibited the pacemaking potentials in a dose-dependent manner (n = 15). D: CGP37157 from 10 to 30 µmol/L effectively inhibited Ca²⁺ efflux from mitochondria in the pacemaking activity of ICCs. The IC₅₀ of CGP37157 was 18.2 µmol/L.