IL-1β activates p44/42 and p38 mitogen-activated protein kinases via different pathways in cat esophageal smooth muscle cells

Figure 5 MAP kinase activation by IL-1β was not affected by other kind of MAP kinase, COX and iNOS. (A) MEK inhibitor PD98059 (10 μmol/L, 1 h) reduced the level of p44/42 MAP kinase phosphorylation by IL-1β. SB202190 (30 μmol/L, 1 h), p38 MAP kinase inhibitor, had no effect on the p44/42 MAPK phosphorylation, which blocked p38 MAP kinase activation. (B) Indomethacin (10 μmol/L) and L-NAME (10 μmol/L) had no effect on the activations of p44/42 MAP kinase and p38 MAP kinase by IL-1β.