IL-1β activates p44/42 and p38 mitogen-activated protein kinases via different pathways in cat esophageal smooth muscle cells

Figure 4 IL-1β-induced activation of p44/42 MAP kinase is mediated by PLC and PKC. (A) Neomycin (10 μmol/L, 1 h) decreased the phosphorylated forms of p44/42 MAP kinase. DEDA (10 μmol/L, 1 h) and ρCMB (10 μmol/L, 1 h) had no effect on the IL-1β-induced activation of p44/42 MAP kinase. (B) PKC inhibitors chelerythrine (10 μmol/L, 1 h) and GF109203X (10 μmol/L, 1 h) decreased the active form of p44/42 MAP kinase. All the phospholipase inhibitors and PKC inhibitors failed to regulate the activation of p38 MAP kinase by IL-1β.