Interleukin-1β gene polymorphism associated with hepatocellular carcinoma in hepatitis B virus infection

Table 1 IL-1β and IL-1RN polymorphisms in patients with HBV and healthy controls

Polymorphisms		Patients with HBV		Healthy controls n = 152 (%)
		Without HCCn = 90 (%)	With HCCn = 46 (%)
IL-1B-511
	Genotype frequencies
	C/C	17 (18.89)	17 (36.96)1,2	31 (20.39)
	C/T	51 (56.67)	21 (45.65)	79 (51.97)
	T/T	22 (24.44)	8 (17.39)	42 (27.63)
	Allele frequencies
	C	85 (47.22)	55 (59.78)3	141 (46.38)
	T	95 (52.78)	37 (40.22)	163 (53.62)
IL-1RN
	Genotype frequencies
	1/1	74 (82.22)	38 (82.61)	121 (79.61)
	1/2	15 (16.67)	8 (17.39)	29 (19.08)
	2/2	1 (1.11)	0	1 (0.66)
	1/4	0	0	1 (0.66)
	Allele frequencies
	1	163 (90.56)	84 (91.30)	272 (89.47)
	2	17 (9.44 )	8 (8.70)	31 (10.20)
	4	0	0	1 (0.33)

¹P = 0.036 vs healthy controls, OR (95%CI) = 2.29 (1.05–4.97); ²P = 0.036 vs patients without HCC, OR (95%CI) = 2.52 (1.05–6.04); ³P = 0.033 vs healthy controls, OR (95%CI) = 1.72 (1.04–2.84).