A head to head comparison of oral vs intravenous omeprazole for patients with bleeding peptic ulcers with a clean base, flat spots and adherent clots

Table 1 Baseline characteristics of the study groups

Characteristics	Group 1(iv)(n = 112)	Group 2(po)(n = 99)	Total(n = 211)	P
Male / Female (n)	79/33	66/33	145/66	0.545
Age (mean ± SD)	52.7 ± 17.05	52.8 ± 19.61	52.7 ± 18.12	0.9661
Age < 65 yr [n (%)]	80 (71.4)	64 (64.6)	144 (68.2)	0.291
Age ≥ 65 yr [n (%)]	32 (28.6)	35 (35.4)	67 (31.8)
Ulcer site (n):
-Duodenal	94	76	160	0.083
-Gastric	18	23	51
Endoscopic signs (n):
-Clean base	82	62	144	0.244
-Flat spot	20	26	46
-Old adherent clot	10	11	21
Ulcer size (cm)	1.05 ± 0.4	1.06 ± 0.6	1.05 ± 0.5	0.9341
Ulcer count (n):
-Single	106	82	188	0.0072
-Multiple	6	17	23
Ulcer locations (n):
-Posterior duodenal	61	52	113	0.007
-Anterior duodenal	33	14	47
-Gastric corporal	9	16	25
-Gastric antral	9	17	26
Aspirin/NSAIDs use [n (%)]	68 (60.7)	70 (70.7)	138 (65.4)	0.072
H pylori positive [n (%)]	63 (56.3)	56 (56.6)	119 (56.4)	0.963
Previous eradication [n (%)]	10 (8.9)	3 (3.0)	13 (6.2)	0.092
Coexisting illness [n (%)]	41 (36.6)	35 (35.4)	76 (36.1)	0.850
-Cardiac (n)	18	14	32
-Pulmonary (n)	16	15	31
-Cerebral (n)	7	6	13
Previous surgery [n (%)]	19 (17.0)	22 (22.2)	41 (19.4)	0.335
Alcohol [n (%)]	5 (4.5)	2 (2.0)	7 (3.3)	0.4522
Smoking [n (%)]	47 (42.0)	38 (38.4)	85 (40.3)	0.597
Previous pain [n (%)]	72 (64.3)	67 (67.7)	139 (65.9)	0.604
Previous bleeding [n (%)]	17 (15.2)	17 (17.2)	34 (26.1)	0.694
Hematemesis [n (%)]	77 (68.8)	69 (69.7)	146 (69.2)	0.882
Coagulopathy [n (%)]	4 (3.5)	3 (3.0)	7 (3.3)	0.9172
Hematocrit (%, Mean)	24.2 ± 3.2	23.6 ± 3.4	23.9 ± 3.1	0.5671
Index hematocrit < 25% (n) Index hematocrit ≥ 25% (n)	47 65	45 54	92 119	0.610
Shock (n)	6	5	11	0.3812
Rockall score ≤ 3 [n (%)]	63 (56.3)	52 (52.5)	115 (54.5)	0.737
> 8 [n (%)]	21 (18.7)	19 (19.1)	40 (18.9)	0.865

¹Student’s t test;

²Fisher’s exact test; NSAIDs: non-steroidal anti-inflammatory drugs.