Bone morphogenetic protein-2 is a negative regulator of hepatocyte proliferation downregulated in the regenerating liver

Figure 3 MTT assay of human hepatoma Huh7 cell line treated for 72 h with various concentrations of BMP2. Values obtained with no BMP2 were set at 100. Error bars represent the standard error of the mean. BMP-2 inhibited the growth of Huh7 cells, maximal effects occurring at 100 ng/mL after 72 h incubation. BMP-2 significantly inhibited the growth of Huh7 cells by 38.8% ± 0.4% (P < 0.01).