Folate levels in mucosal tissue but not methylenetetrahydrofolate reductase polymorphisms are associated with gastric carcinogenesis

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Dec 21, 2006 (publication date) through Aug 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Gastric Cancer

World J Gastroenterol. Dec 21, 2006; 12(47): 7591-7597
Published online Dec 21, 2006. doi: 10.3748/wjg.v12.i47.7591

Table 2 Folate level and transcription and methylation of c-myc

Methylationstatus	Transcription	Casenumber(n)	P¹	Average folateconcentration(μg/L)	P²
Hypomethylated	Up-regulated	6		2.25 ± 1.23
	Unchanged	0	0.02		0.06
Methylated	Up-regulated	13		3.91 ± 2.01
	Unchanged	19

¹Transcription and DNA methylation of c-myc; ²Folate concentration and DNA methylation of c-myc.

Citation: Weng YR, Sun DF, Fang JY, Gu WQ, Zhu HY. Folate levels in mucosal tissue but not methylenetetrahydrofolate reductase polymorphisms are associated with gastric carcinogenesis. World J Gastroenterol 2006; 12(47): 7591-7597
URL: https://www.wjgnet.com/1007-9327/full/v12/i47/7591.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i47.7591