Toxicological study of the hepatotherapeutic herbal formula, Chunggan extract, in beagle dogs

Figure 3 Histopathological findings. On the final day of the subacute toxicological experiment, 13 main organs (indicated in the text) were removed from each dog, and microscopic examinations were carefully performed after a general H&E staining process. Livers, lungs, kidneys, spleens, and stomachs from the control and the group fed CGX revealed uniformly rare focal pathological findings. This figure presents the only pathological findings among livers and kidneys from the control and the group treated with the highest level of CGX, such as focal necrosis and hyperemia in livers, and glomerular hyperemia in kidneys (HE stain, X 200). LMC: liver from male control; LFC: liver from female control; LMH: liver from male high dose (400 mg/kg); LFH: liver from female high dose (400 mg/kg); KMC: kidney from male control; KFC: kidney from female control; KMH: kidney from male high dose (400 mg/kg); KFH: kidney from female high dose (400 mg/kg).