Acute fatty liver of pregnancy: An update on pathogenesis and clinical implications

Figure 3 The structure of MTP subunit cDNA’s. The MTP α-subunit contains 20 exons. Exons 1 and 2 encode the transit peptide that directs uptake into the mitochondria which is proteolytically cleaved during translocation into the mitochondria. Exons 3-8 encode the N-terminus of the mature α-subunit containing the long-chain 2,3-enoyl-CoA hydratase activity. Exon 9 encodes the region known as a linker domain. Exons 11-20 encode the C-terminus of the mature α-subunit containing the LCHAD activity. The MTP β-subunit has 16 exons that encode the long-chain 3-keto-acyl CoA thiolase activity.