Reversibility of central neuronal changes in patients recovering from gallbladder stones or acute cholecystitis

Table 1 Characteristics of the 5 patients still intermittently suffering from pain

Patient (n)	Pain localization	Attack frequency	Pain duration	Physical activity	Accompanying symptoms	VAS	Pain-killers	Anti-depressive
C (4)	Epigastriel	Daily	h	Depending on activity	Feeling ill and nausea	9	Paracetamol	No
C (5)	Under the right costal margin	Every 3rd wk	20-30 s	Sitting down	No	7		SSRI
C (14)	Under the right costal margin	Approximately 3 every week	min	Sitting down	No	4	No	No
C (17)	Epigastriel and under the right costal margin	2-3/mo	h	Depending on activity	Nausea and reflux for 1-2 d	7	NSAID and paracetamol	TCA
AC (15)	Under the right costal margin	2-3/yr	min	Standing	No	6	No

C: Cholecystholithiasis study[10]; AC: Acute cholecystitis study[9]; VAS: Visual analogue scale; NSAID: Non steroid anti-inflammatory drug; SSRI: Selective serotonin reuptake inhibitor; TCA: Tricyclic anti-depressants.