Toxicological study of the hepatotherapeutic herbal formula, Chunggan extract, in beagle dogs

Table 2 Haematological analysis after administration of Chunggan extract for 4 wk

Number of dogs	Male (12)				Female (12)
CGX (mg/kg•d)	0	100	200	400	0	100	200	400
Erythrocyte (M/UL)	6.4 ± 0.6	6.80 ± 0.4	6.56 ± 0.4	6.70 ± 0.1	6.22 ± 0.5	6.70 ± 0.5	6.77 ± 0.5	6.59 ± 0.2
Hemoglobin (g/dL)	18.6 ± 2.1	17.6 ± 0.4	18.2 ± 1.0	18.1 ± 1.3	16.5 ± 1.7	17.5 ± 1.8	17.8 ± 0.4	17.7 ± 0.1
Hematocrit (%)	41.3 ± 4.1	42.8 ± 1.8	42.8 ± 2.2	42.2 ± 1.0	39.2 ± 2.8	40.1 ± 2.1	43.3 ± 3.9	41.6 ± 0.9
MCV (fL)	64.1 ± 0.3	63.1 ± 2.4	65.4 ± 2.8	62.9 ± 1.0	63.1 ± 0.1	60.1 ± 4.1	63.9 ± 1.4	63.1 ± 1.9
MCH (pg)	28.9 ± 1.1	26.0 ± 1.4	27.8 ± 2.3	27.0 ± 1.7	26.5 ± 1.2	26.1 ± 2.7	26.4 ± 2.4	26.8 ± 0.7
MCHC (g/dL)	45.2 ± 1.5	41.7 ± 0.6a	42.4 ± 2.2	42.9 ± 2.2	42.1 ± 2.2	43.5 ± 2.5	41.3 ± 4.6	42.6 ± 0.7
RDW (%)	15.1 ± 0.1	15.9 ± 0.3	15.3 ± 0.4	15.9 ± 0.3	15.7 ± 0.1	15.9 ± 0.6	15.7 ± 0.5	15.1 ± 0.1
Reticulocytes (%)	0.30 ± 0.1	0.23 ± 0.1	0.37 ± 0.2	0.43 ± 0.2	0.77 ± 0.2	0.50 ± 0.4	0.53 ± 0.6	0.50 ± 0.2
Platelets (k/UL)	349 ± 13	320 ± 125	334 ± 50	344 ± 46	347 ± 94	333 ± 90	239 ± 87	245 ± 18
MPV (fL)	12.8 ± 0.3	15.1 ± 1.2	14.6 ± 2.2	14.0 ± 1.3	13.4 ± 1.6	12.8 ± 1.6	16.4 ± 4.2	15.0 ± 4.7
PT (s)	6.73 ± 0.2	7.20 ± 0.6	6.63 ± 0.3	6.77 ± 0.2	6.73 ± 0.3	7.00 ± 0.4	6.77 ± 0.1	6.93 ± 0.5
aPTT (s)	14.2 ± 0.5	19.3 ± 5.2	15.4 ± 0.7	15.2 ± 0.9	15.7 ± 0.2	15.4 ± 0.9	16.1 ± 2.6	16.5 ± 0.7
Leukocytes (k/UL)	9.86 ± 1.2	9.51 ± 1.3	8.56 ± 1.3	11.4 ± 1.4	9.64 ± 1.3	10.6 ± 0.2	11.8 ± 3.8	8.9 ± 1.6
Neutrophil (%)	61.0 ± 10	59.8 ± 15	65.7 ± 14	66.9 ± 10	57.0 ± 13	60.9 ± 14	49.2 ± 2.3	62.8 ± 13
Lymphocyte (%)	19.5 ± 4.1	23.7 ± 4.2	21.4 ± 4.7	21.8 ± 2.6	28.2 ± 5.2	26.7 ± 8.5	35.5 ± 13	27.1 ± 7.9
Monocytes (%)	7.5 ± 2.0	8.0 ± 3.2	6.9 ± 1.2	5.3 ± 0.9	7.2 ± 1.0	7.6 ± 5.7	10.4 ± 5.1	7.8 ± 2.2
Eosinophil (%)	11.6 ± 9.1	8.41 ± 4.2	5.96 ± 5.8	5.70 ± 1.7	7.47 ± 11	4.25 ± 1.9	4.15 ± 1.7	2.70 ± 2.4
Basophil (%)	0.30 ± 0.3	0.11 ± 0.1	0.12 ± 0.3	0.26 ± 0.2	0.31 ± 0.6	0.13 ± 0.1	0.34 ± 0.5	0.11 ± 0.1

After administration of Chunggan extract (CGX) for 4 wk, haematology was analysed to compare CGX-treated groups to the control group. MCV: Mean corpuscular volume; MCH: Mean corpuscular haemoglobin; MCHC: Mean corpuscular haemoglobin concentration; RDW: Red cell distribution width; MPV: Mean platelet volume; PT: Prothrombin time; APPT: Activated partial thromboplastin time. aindicates a significant difference at a level of P < 0.05.