Toxicological study of the hepatotherapeutic herbal formula, Chunggan extract, in beagle dogs

Table 1 Summary for clinical observation and histological examination

CGX (mg/kg per day)	0	100	200	400
Mortality	-	-	-	-
Clinical signs	NAD	NAD	NAD	NAD
Anorexia	-	-	-	-
Soft feces	-	-	-	-
Food intake	NAD	NAD	NAD	NAD
Ophthalmologic findings	NAD	NAD	NAD	NAD
Relative organ weight	NS	NS	NS	NS
Necropsy findings	NAD	NAD	NAD	NAD
Histopathological findings	Rarely in some samples	Rarely in some samples
Liver	Focal necrosis	Subcutaneous necrosis
Lung	Yellow pigmentation	Yellow pigmentation
Kidney	Glomerular hyperemia	Glomerular hyperemia
Spleen	White pulp atrophy	White pulp atrophy
Stomach	Helicobacter	Helicobacter

Three male and three female beagle dogs in each group were fed CGX, and the clinical symptoms including mortality were monitored for 4 wk. At the end of the experiment, ophthalmologic, necropsy-based, and histopathological examinations were performed. NAD: No abnormality detected; NS: Not significant; -: Absent.