Transplantation of fetal liver epithelial progenitor cells ameliorates experimental liver fibrosis in mice

Figure 3 Effect of FLEP cell transplantation on liver fibrosis by HE staining and immunohistochemistry of α-SMA. A: Normal liver tissue in control group (HE staining); B: Liver fibrosis in model group, fibrous tissue was formed with inflammatory cell infiltration in liver (HE staining); C: Liver fibrosis in FLEP cell transplantation group. The pathological change of liver was rather lighter compared with the model group (HE staining). D: Normal liver tissue, only α-SMA expression of vascular smooth muscle cell (immunohistochemical staining); E: Liver tissue in model group, displaying an increased amount of α-SMA expression with a dense network (immunohistochemical staining); F: Liver tissue in FLEP cell transplantation group, α-SMA expression was reduced compared with the model group (immunohistochemical staining). (original magnification, × 200).