Safety and efficacy of hepatitis A vaccine in children with chronic liver disease

Table 4 Comparison of liver function tests before and after vaccination

	Before vaccination		After vaccination		P
	Range	Median	Range	Median
Patients
Total Serum Bilirubin (mg/L)	4-210	7	3-250	7.5	9.5
ALT (IU/L)	19-163	42	19-136	27.5	0.11
AST (IU/L)	28-299	38	30-288	43	0.07
Controls
Total Serum Bilirubin (mg/L)	3-6	5	1-6	4	4.8
ALT (IU/L)	9-21	18	10-27	17	0.93
AST (IU/L)	21-39	27	21-57	31	0.01b

^bP < 0.01 vs controls before and after vaccination (Wilcoxon Signed Ranks Test). ALT: alanine aminotransferase; AST: aspartate aminotransferase.