Differences in viral kinetics between genotypes 1 and 3 of hepatitis C virus and between cirrhotic and non-cirrhotic patients during antiviral therapy

Table 3 Mean viral kinetic parameters for each HCV genotype and histological status

HCVgenotype	Histologystatus	n	Baseline viralload(log IU/mL)	1st phasedecline1(log IU/mL)	2nd phaseslope1(log/wk)
1	cirrhotics	7	5.9	0.69	0.06
	non-cirrhotics	21	6	1.03a	0.18a
Total		28	5.9	0.95	0.15
3	cirrhotics	5	6.4c	1.89b	0.57b
	non-cirrhotics	13	5.7	1.65b	0.99b
Total		18	5.9	1.72d	0.87d

¹Treatment during the 1^st phase decline was equal in all dosing groups and no significant difference was found in the 2^nd phase decline slope between the dosing groups (Table 2), thus the effect of histological status was studied in all dosing groups together.

^aP < 0.02 vs cirrhotic genotype 1 patients;

^cP < 0.03 vs all other patients;

^bP < 0.01,

^dP < 0.001 vs genotype 1 patients.