Protective effects of amphetamine on gastric ulcerations induced by indomethacin in rats

doi:10.3748/wjg.v12.i44.7168

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Nov 28, 2006 (publication date) through Nov 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2006; 12(44): 7168-7171
Published online Nov 28, 2006. doi: 10.3748/wjg.v12.i44.7168

Table 2 Effect of amphetamine on number and severity of indomethacin-induced gastric ulcerations (mean ± SE)

Groups		Number ofulcerations/stomach		Severity
Groups		TU	LU	UI
I (9)	I₅₀	12.44 ± 3.69	10.11 ± 3.74	1.61 ± 0.31
II (9)	I₅₀ + A₁₀	7.33 ± 1.89	5.44 ± 1.52	1.22 ± 0.25
III (9)	I₅₀ + A₂₅	5.33 ± 2.38	3.11 ± 1.9	0.72 ± 0.21^a
IV (8)	I₅₀ + A₅₀	2.25 ± 1.91^c	1.0 ± 1.0^c	0.31 ± 0.19^b

The subscript indices represent the doses expressed as μmol/kg. I: Indomethacin; A: Amphetamine. TU: Total number of ulcerations; LU: Large ulcerations (> 1 mm); UI: Ulcer index.

^aP < 0.05,

^bP < 0.01,

^cP < 0.05 vs groupI.

Citation: Sandor V, Cuparencu B, Dumitrascu DL, Birt MA, Krausz TL. Protective effects of amphetamine on gastric ulcerations induced by indomethacin in rats. World J Gastroenterol 2006; 12(44): 7168-7171
URL: https://www.wjgnet.com/1007-9327/full/v12/i44/7168.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i44.7168