Protective effects of amphetamine on gastric ulcerations induced by indomethacin in rats

doi:10.3748/wjg.v12.i44.7168

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Nov 28, 2006 (publication date) through Nov 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2006; 12(44): 7168-7171
Published online Nov 28, 2006. doi: 10.3748/wjg.v12.i44.7168

Table 1 Effect of amphetamine on incidence and severity of indomethacin-induced gastric ulcerations (%)

Groups		TU	LU	PR
I	I₅₀	100	100
II	I₅₀ + A₁₀	88.89	77.778	(+) 24.138
III	I₅₀ + A₂₅	77.78	66.667	(+) 55.172¹
V	I₅₀ + A₅₀	37.5^a	12.5^a	(+) 80.603¹

The subscript indices represent the doses expressed as μmol/kg.I: Indomethacin; A: Amphetamine; TU: Total number of ulcerations; LU: Large ulcerations (> 1 mm); PR: Protection ratio.

^aP < 0.05 vs groupI(Fischer’s exact probability and median’s test);

¹Significant at PR > (+) 33.33%.

Citation: Sandor V, Cuparencu B, Dumitrascu DL, Birt MA, Krausz TL. Protective effects of amphetamine on gastric ulcerations induced by indomethacin in rats. World J Gastroenterol 2006; 12(44): 7168-7171
URL: https://www.wjgnet.com/1007-9327/full/v12/i44/7168.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i44.7168