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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 21, 2006; 12(43): 6926-6932
Published online Nov 21, 2006. doi: 10.3748/wjg.v12.i43.6926
Published online Nov 21, 2006. doi: 10.3748/wjg.v12.i43.6926
Figure 2 Possible mechanisms for the direct profibrotic effects of ethanol on hepatic stellate cells.
Acetaldehyde, together with ethanol or acetaldehyde-derived oxidative stress, induces latent TGFβ1 and TGFβ receptor activation that subsequently leads to Smad3/4 activation and binding to the promoter of collagen I genes. PKC and/or PI-3K kinases are also activated by acetaldehyde. Both kinase systems activate their downstream components, including ERK1/2 and JNK. As a result, C/EBP, NF-1 and/or BTEB transcription factors are activated and therefore up-regulate collagen I gene transcription.
- Citation: Wang JH, Batey RG, George J. Role of ethanol in the regulation of hepatic stellate cell Function. World J Gastroenterol 2006; 12(43): 6926-6932
- URL: https://www.wjgnet.com/1007-9327/full/v12/i43/6926.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i43.6926