Meta-analysis on inoperable pancreatic cancer: A comparison between gemcitabine-based combination therapy and gemcitabine alone

Table 2 Toxic effects recorded from randomized controlled trials (Grade 3-4 toxic effects)

Studies	Intervention	Neutrophils	Platelets	Anemia	Infection	Nausea/vomit	Mucositis	Diarrhea
Scheithauer2003[8]	Gem	3/39	1/39	0	0	0	0	0
	Gem + Capecitabine	4/40	0	2/40	0	0	0	2/40
Colucci 2002[9]	Gem	5/53	1/53	2/53	-	1/53	1/53	0
	Gem + DDP	9/51	1/51	3/51	-	1/51	0	2/51
Wang XY 2002[10]	Gem	5/19	7/19	2/19	-	0	-	-
	Gem + DDP	7/21	8/21	9/21	-	2/21	-	-
Gansauge2002[11]	Gem	-	-	-	-	3/28	-	1/28
	Gem + NSC-631570	-	-	-	-	1/18	-	0
Berlin 2002[12]	Gem	8/158	17/158	16/158	-	30/158	3/158	/158
	Gem + 5-FU	11/158	30/158	16/158	-	29/158	2/158	/158
Bramhall 2002[13]	Gem + placebo	9/119	-	7/119	12/119	16/119	-	-
	Gem + marimastat	3/120	-	3/120	11/120	13/120	-	-
Cutsem 2004[14]	Gem + placebo	103/342	41/342	55/342	-	58/342	-	10/342
	Gem + R115777	132/331	50/331	66/331	-	46/331	-	13/331
Louvet 2005[15]	Gem	2/156	5/156	16/156	-	12/156	-	2/156
	Gem + Oxaliplatin	2/157	22/157	10/157	-	30/157	-	9/157
Reilly 2004[16]	Gem	24/157	7/157	13/157	-	17/157	-	2/157
	Gem + DX-8951f	50/168	28/168	11/168	-	33/168	-	6/168
Richards 2004[17]	Gem	35/273	17/273	8/273	-	18/273	-	2/273
	Gem + Pemetrexed	123/273	49/273	38/273	-	18/273	-	8/273
Li CP 2004[18]	Gem	2/25	1/25	2/25	-	-	-	-
	Gem + DDP	4/21	5/21	2/21	-	-	-	-
Reni 2004[19]	Gem	9/47	1/47	2/47	-	4/47	1/47	-
	Gem + 5-FU + DDP + EPI	22/52	15/52	2/52	-	3/52	2/52	-
Viret 2004[20]	Gem	16/40	5/40	11/40	-	3/40	-	-
	Gem + DDP	23/41	14/41	14/41	-	9/41	-	-
Rocha Lima 2004[21]	Gem	54/169	24/169	22/169	-	31/169	-	3/169
	Gem + Irinotecan	65/173	34/173	27/173	-	53/173	-	33/173
Costanzo 2001[22]	Gem	1/49	0	3/49	-	0	0	0
	Gem + 5-FU	1/41	1/41	3/41	-	1/41	2/41	0
Heinemann 2003[23]	Gem	8/97	10/97	10/97	2/97	6/97	2/97	4/97
	Gem + DDP	10/95	4/95	13/95	1/95	21/95	4/95	3/95
Kulke 2004[24]	Gem	27/58	15/58	6/58	6/58	13/58	-	1/58
	Gem + DDP	29/62	27/62	11/62	2/62	24/62	-	0/62
	Gem + Docetaxel	19/65	7/65	8/65	8/65	10/65	-	5/65
	Gem + Irinotecan	12/60	9/60	4/60	4/60	17/60	-	10/60
Moore2005[26]	Gem + Erlotinib	71/282	28/282	34/282	45/282	20/282	<1	17/282
	Gem + placebo	73/280	34/280	34/280	39/280	20/280	0	6/280
Stathopoulos 2005[27]	Gem	8/70	0/70	2/70	0	1/70	0	2/70
	Gem + Irinotecan	10/60	2/60	2/60	0	1/60	0	2/60
Riess 2005[28]	Gem	27/225	15/225	15/225	19/225	16/225	-	9/225
	Gem + 5-FU/CF	26/220	28/220	18/220	12/220	30/220	-	8/220
Herrmann 2005[29]	Gem	30/153	7/153	9/153	-	5/153	1/153	3/153
	Gem + Capecitabine	34/155	8/155	9/155	-	8/155	0/155	8/155

5-FU: 5-fluororacil; EPI: Epirubicin.