Review
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 21, 2006; 12(43): 6941-6948
Published online Nov 21, 2006. doi: 10.3748/wjg.v12.i43.6941
Table 2 Gene delivery vectors
VectorBrief descriptionReference (s)
Cationic liposomesSpherical vesicle made of positively charged lipids, efficient uptake of DNA by the cell46, 47
Low Voltage ElectroporationEntry of DNA into the cell whose membrane is permeabilized by electric field, efficient gene transfer is ensured48, 49
NanoparticlesSubmicron-sized particle with the therapeutic agent situated within the matrix or on the surface3, 45
Measles virusContains negative strand RNA molecule, can enter tumor cells without the defensive responses of the tumor44
Herpes simplex virusDobule stranded DNA virus, wide host range, large transgene capacity, long-lasting effect3, 44
LentivirusDerived from HIV, can achieve stable integration of the gene in non-dividing cells3, 44
RetrovirusBased on murine leukemia virus, foreign cDNA can be incorporated into host cell genome with high efficiency3, 44
Replication-competent Retrovirus (RCR)Modified retroviral vector that can replicate in solid tumor model so the transfer efficiency is enhanced55, 56
Semliki Forest Virus (SFV)One type of alphavirus, modification of its RNA genome yield a new expression vector that transfers transgene into tumor50, 51, 52, 53, 54
Recombinant adenovirus (rAdv)Double stranded DNA virus, can be produced in high titres and deliver transgene efficiently Special engineered adenovirus: oncolytic and gutless3, 57, 58, 59, 60, 61, 62, 63, 64
Recombinant adeno-associated virus (rAAV)Possess the advantages of rAdv and retrovirus, low level of immune response3, 25, 65, 66, 67, 68