A single dose of caffeic acid phenethyl ester prevents initiation in a medium-term rat hepatocarcinogenesis model

Figure 5 CAPE protects from genotoxic damage caused by DEN and MNNG in PHC. A: DEN at 1.25 μmol/L concentration induced ³HdT incorporation and this dose was tested with several concentrations of CAPE (0.625, 1.25, 2.5, 5 and 10 μmol/L). CAPE decreased DEN genotoxic damage to levels even below the control; B: Curve concentration of MNNG from 0.625-10 μmol/L. One dose of 5 μmol/L of CAPE protects from genotoxic damage caused by MNNG in PHC. Data incorporation of ³HdT was estimated as dpm/mg of DNA and results are expressed as percent of control samples, the zero data represent ³HdT incorporation of basal level of control group. Results were obtained from 3 replicates of at least 3 animals. ^aP < 0.05 vs DEN only; ^cP < 0.05 vs MNNG only.