A single dose of caffeic acid phenethyl ester prevents initiation in a medium-term rat hepatocarcinogenesis model

Figure 4 Effect of CAPE on LPX levels induced by DEN. LPX was determined by detection of malonyldialdehyde concentration and expressed as TBARS. DEN increased TBARS levels detected at 12 h. CAPE administered 12 h before the initiator, clearly reduced the TBARS induced by DEN. Six hundred microgram of liver homogenates of each treated group were used, group NT, DEN (12 h after) and DEN plus CAPE (24 h after CAPE administration). Results were statistically significant with ^aP < 0.05.