A single dose of caffeic acid phenethyl ester prevents initiation in a medium-term rat hepatocarcinogenesis model

Figure 1 CAPE administration protocol. A: Carcinogenic treatment (CT): at time 0 the rats were treated with 200 mg/kg of DEN; on d 7, 8 and 9, 2-AAF was administered by gavage at doses of 20 mg/kg per day, a PH was performed at d 10 and rats were sacrificed at d 25; B: CAPE (↓) was administered 12 h before DEN.