Inhibition of hepatic tumor cell proliferation in vitro and tumor growth in vivo by taltobulin, a synthetic analogue of the tripeptide hemiasterlin

Figure 1 Inhibitory effect of HTI-286 on proliferation of MH, HepG2, and Hep3B cells. Inhibitory effect upon HTI-286 treatment was highly significant in all three hepatic carcinoma cell lines. MH (A), HepG2 (B) and Hep3B (C) cells were exposed to 1, 3, and 3 nmol/L of HTI-286, respectively, for two cell doubling times. Student’s t test analysis showed two-sided P values of 0.005, 0.002 and 0.001 for MH, HepG2, and Hep3B, respectively.