Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats

doi:10.3748/wjg.v12.i42.6835

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Nov 14, 2006 (publication date) through Aug 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2006; 12(42): 6835-6841
Published online Nov 14, 2006. doi: 10.3748/wjg.v12.i42.6835

Table 2 Serum hyaluronate levels, liver collagen content by biochemical method and collagen surface density by image analysis of groups at the end of 4^th wk of study (mean ± SE)

parameter	Vit C	Vit E	Vit EC	Sham	Control
Liver collagen content microgram collagen/mg protein	32.7 ± 1.2^b^d	33.8 ± 2.9^b^d	36.7 ± 0.5^a^d	23.8 ± 1.3^d	48.3 ± 0.6^a
Collagen surface density (%)	7.0 ± 1.1^c	6.2 ± 1.7^c	12.3 ± 2.0^c	2.6 ± 0.7^c	17.4 ± 5.6
Hyaluronate (ng/mL)	63 ± 25^d	87 ± 28^d	47 ± 25^d	56 ± 16^d	783 ± 111

^aP < 0.001 ,

^bP < 0.01 vs sham;

^cP < 0.05 ,

^dP < 0.001 vs control.

Citation: Soylu AR, Aydogdu N, Basaran UN, Altaner S, Tarcin O, Gedik N, Umit H, Tezel A, Dokmeci G, Baloglu H, Ture M, Kutlu K, Kaymak K. Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats. World J Gastroenterol 2006; 12(42): 6835-6841
URL: https://www.wjgnet.com/1007-9327/full/v12/i42/6835.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i42.6835