Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats

Table 1 Liver biochemical tests and relative liver and spleen weights of rats at the end of 4^th wk of bile duct obstruction (mean ± SE)

parameter	Vit C	Vit E	Vit EC	Sham	Control
AST (IU/L)	548 ± 82	446 ± 75b	505 ± 58a	223 ± 26	473 ± 64a
ALT (IU/L)	156 ± 34	148 ± 16	156 ± 23	98 ± 9	165 ± 29
ALP (IU/L)	446 ± 95	403 ± 41	396 ± 27	296 ± 35	477 ± 59
GGT (IU/L)	64 ± 13	86 ± 5	74 ± 8	64 ± 4	101 ± 17
Total bilirubin (mg/dL)	5.9 ± 1.2d	7.2 ± 0.9d	7.1 ± 1.3d	0.5 ± 0.2	8.4 ± 1.4d
Conjugated bilirubin (mg/dL)	3.9 ± 0.6d	3.7 ± 1.0d	3.5 ± 0.6d	0.2 ± 0.1	4.2 ± 0.7d
Albumin (g/dL)	3.2 ± 0.1b	3.0 ± 0.1a	3.3 ± 0.2	3.8 ± 0.0	2.9 ± 0.1d
Relative liver weight (%)	5.9 ± 0.4a	5.6 ± 0.6a	5.9 ± 0.5b	3.4 ± 0.6	5.9 ± 0.1d
Relative spleen weight (%)	0.40 ± 0.07	0.39 ± 0.08	0.42 ± 0.08	0.34 ± 0.04	0.44 ± 0.05

AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transferase; T. bilirubin: Total bilirubin; C. Bilirubin: Conjugated bilirubin.

^aP < 0.05 ,

^bP < 0.01,

^dP < 0.001 vs sham.