Inhibition of human gastric carcinoma cell growth by atofluding derivative N3-o-toluyl-fluorouracil

Table 1 Enhancement of TFU induces growth inhibition of SGC-7901 and NKM-45 cells in the presence of liver microsomal enzymes

Cell line	Time (h)	Inhibition (%)
		0.1 μg/mL	1 μg/mL	10 μg/mL	100 μg/mL	1000 μg/mL
SGC-7901
	24	4.73	8.21	11.92	14.84	24.08
	48	9.56	15.10	22.31	36.02	39.89
	72	17.29	24.35	30.75	40.03	43.72
	96	22.03	31.76	32.97	42.43	45.51
	120	37.67	36.67	35.24	45.86	48.57
MKN-45
	24	9.00	18.38	20.00	36.99	42.02
	48	20.00	34.00	40.00	51.40	55.00
	72	45.09	52.63	57.11	58.18	60.16
	96	52.50	61.64	57.87	55.53	61.41
	120	59.19	62.02	59.12	55.84	53.98

Enhancement was calculated using the inhibition rate in the presence of microsomal enzymes minus the inhibition rate in the absence of enzymes at the same concentration.