Hematopoietic cell transplantation for Crohn’s disease; is it time?

Table 3 Autologous transplant cases

	Demographics & indicationfor HCT	Disease activitybeforeHCT	Complications of CD	Duration of CD(yr)	Mobilization Conditioning		T cell deplet	Length of follow-up(mo)	Remiss. of CD	Ongoing meds
Oyama[53]	21 Female CD	Active	Fistulae, Surgery	10	Cy + GCSF	Cy + ATG	Yes	37	Yes	No
	16 Male CD	Active	Fistulae, Obstruction, GR	7	Cy + GCSF	Cy + ATG	Yes	36	Yes	No
	38 Female CD	Active	Fissures, Obstruction, Surgery	20	Cy + GCSF	Cy + ATG	Yes	27	Yes	No
	27 Female CD	Active	Fistulae, EIM, Surgery	12	Cy + GCSF	Cy + ATG	Yes	25	No	Mtx, pred.
	35 Male CD	Active	Fistulae, Obstruction, Surgery	12	Cy + GCSF	Cy + ATG	Yes	24	Yes	No
	27 Female CD	Active	Fistula, Surgery	6	Cy + GCSF	Cy + ATG	Yes	20	Yes	No
	25 Male CD	Active	Perianal disease, Surgery	13	Cy + GCSF	Cy + ATG	Yes	17	Yes	No
	15 Male CD	Active	EIM, GR, Surgery	8	Cy + GCSF	Cy + ATG	Yes	16	Yes	No
	31 Female CD	Active	Perianal disease, EIM, Surgery	10	Cy + GCSF	Cy + ATG	Yes	14	Yes	No
	37 Male CD	Active	Perianal disease	6	Cy + GCSF	Cy + ATG	Yes	14	Yes	No
	16 Male CD	Active	Fistula, EIM	1.5	Cy + GCSF	Cy + ATG	Yes	7	Yes	No
	27 Male CD	Active	Perforation, EIM, Surgery	14	Cy + GCSF	Cy + ATG	Yes	7	Yes	No
Scime[58]	55 Male CD	Active	EIM	2	Cy + GCSF	Cy + ATG	Yes	5	Yes	No
Kreisel[59]	36 Male CD	Active	Fistulae, Abscess, Surgery	14	Cy + GCSF	Cy	Yes	10	Yes	Mtx, pred.
Soderholm[52]	57 Female AML	NS	Obstruction, Fistula, Surgery	NS	NS	Cy + TBI	No	60	Yes	No
Musso[60]	30 Male Hodgkin’s Lymph.	Active	Surgery	10	Cy + GCSF	Idarubicin Melphalan	NS	39	Yes	No
Kashyap[51]	20 Male NHL	NS	Perianal disease, Obstruction, Surgery	8	DHAP	Cy + TBI + VP-16	No	84	Yes	No
Castro[50]	Age NS, Female Breast ca	Active	NS	11	NS	NS	NS	36	Yes	Asacol
Drakos[49]	41 female NHL	Inactive	Fistula, Surgery	22	NS	BCNU + VP- 16 + Cy + Ara-C + melphalan	NS	6	Yes	No

AML: Acute myeloid leukemia; ATG: Antithymocyte globulin; BCNU: Carmustine; CD: Crohn’s disease; Cy: Cyclophosphamide; D: Duration of Crohn’s disease in years; DHP: Dexamethasone, high dose Ara-C, platinum; EIM: Extraintestinal manifestation; GR: Growth retardation; NHL: Non Hodgkin’s lymphoma; NS: Not stated; TBI: Total body irradiation. VP-16: Etoposide; Mtx: Methotrexate; pred: prednisone; Remiss: Remission; meds: medications; deplet: depletion.