Hematopoietic cell transplantation for Crohn’s disease; is it time?

Table 1 Allogeneic transplant cases

	Demographics& indicationfor HCT	DiseaseactivitybeforeHCT	Complicationsof IBD beforeHCT	IBD duration(yr)	Donortype	Conditioningtherapy	T celldeplet.
Ditschkowski et al[46] Total 11 patients CD-7 UC-4	Median age 41 Male: 5 Female: 6 CML: 9 AML: 1 MDS: 1	Inactive: 5 Low Act: 6	Fistulae: 3 Obstruction: 2 EIM: 2 Surgery: 4	Median: 10	HLA- identical sibling - 8 HLA- identical unrelated donor- 2 Mismatched unrelated donor- 1	TBI + Cy: 6 TBI + Cy + ATG: 1 TBI + Cy + ATG + thiotepa: 1 TBI + Cy + thiotepa:1 Busulfan + Cy: 2	Yes: 3 No: 8
Lopez-Cubero et al[47]	27 Male CML	Inactive	EIM	11	HLA- match brother	TBI + Cy	No
	27 Male CML	Active	Obstruction Fistula	5	HLA- match sister	TBI + Cy	No
	41 Male CML	Active	Surgery Fistula EIM	9	HLA- match sister	TBI + Cy	No
	41 Male CML	Active	Sclerosing cholangitis	8	HLA- match unrelated donor	TBI + Cy	No
	38 Male CML	Active	Surgery EIM, ↑ ALP	3	One antigen mismatched brother	TBI + Cy	No
	46 Male AML	Active	Sclerosing cholangitis	29	HLA- match sister	TBI + Cy	No
Talbot et al[48]	35 Male AML	Active	Surgery	7	HLA- match brother	TBI + Cy	No

ALP: Alkaline phosphatase; AML: Acute myeloid leukemia; ATG: Antithymocyte globulin; CD: Crohn’s disease; CML: Chronic myeloid leukemia; Cy: Cyclophosphamide; EIM: Extraintestinal manifestations; HCT: Hematopoietic cell transplantation; MDS: Myelodysplastic syndrome; TBI: Total body irradiation; UC: Ulcerative colitis; Act: Activity; deplet: depletion.