Hemodynamic and antifibrotic effects of a selective liver nitric oxide donor V-PYRRO/NO in bile duct ligated rats

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Nov 7, 2006 (publication date) through Jul 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 7, 2006; 12(41): 6639-6645
Published online Nov 7, 2006. doi: 10.3748/wjg.v12.i41.6639

Table 4 Liver fibrosis of rats

	Sham		BDL		P
	Placebo n = 9	V-PYRRO/NO n = 12	Placebo n = 12	V-PYRRO/NO n = 10
Area (%)	2.5 ± 0.5	3.1 ± 0.8	12.1 ± 4.3^a	8.4 ± 3.6^c^e	< 0.0001
Liver hydroxyproline (μg/g protein)	164 ± 26	171 ± 49	381 ± 88^a	268 ± 83^c^e	< 0.0001

^aP < 0.05 vs Sham,

^cP < 0.05 vs sham V-PYRRO/NO,

^eP < 0.05 vs BDL placebo.

Citation: Moal F, Veal N, Vuillemin E, Barrière E, Wang J, Fizanne L, Oberti F, Douay O, Gallois Y, Bonnefont-Rousselot D, Rousselet MC, Calès P. Hemodynamic and antifibrotic effects of a selective liver nitric oxide donor V-PYRRO/NO in bile duct ligated rats. World J Gastroenterol 2006; 12(41): 6639-6645
URL: https://www.wjgnet.com/1007-9327/full/v12/i41/6639.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i41.6639