Hemodynamic and antifibrotic effects of a selective liver nitric oxide donor V-PYRRO/NO in bile duct ligated rats

Table 2 Liver and kidney serum function tests of rats

Parameter	Sham		BDL		P
	Placebo n = 9	V-PYRRO/NO n = 12	Placebo n = 12	V-PYRRO/NO n = 10
Urea (mmol/L)	10.2 ± 2.1	7.9 ± 1.7	9.2 ± 1.6	9.5 ± 2.7	NS
Creatinine (μmol/L)	77 ± 25	63 ± 24	66 ± 11	73 ± 18	NS
AST (UI/L)	172 ± 52	123 ± 60	1150 ± 1480a	1164 ± 1349c	< 0.0001
ALT (UI/L)	48 ± 18	55 ± 36	88 ± 47	82 ± 20	NS
Alkaline phosphatases (UI/L)	160 ± 103	148 ± 80	380 ± 197a	367 ± 141c	< 0.001
Bilirubin (μmol/L)	1.0 ± 0.0	1.3 ± 0.5	117.0 ± 22.0a	101.0 ± 30.0c	< 0.0001

^aP < 0.05 vs sham placebo,

^cP < 0.05 vs sham V-PYRRO/NO; NS: Not significant.