Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma

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Nov 7, 2006 (publication date) through Nov 29, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Liver Cancer

World J Gastroenterol. Nov 7, 2006; 12(41): 6620-6626
Published online Nov 7, 2006. doi: 10.3748/wjg.v12.i41.6620

Table 1 Demographic and virologic characteristics of basal core promoter 1762/1764 mutants

Characteristics	Mutant	Wild type	P
Number	124	156
Age (yr) (mean ± SD)	50.9 ± 13.5	46.3 ± 15.9	0.01
Male/Female	93/31	112/44	0.5
Asian/Non-Asian	107/17	121/35	0.06
Genotype, n (%)			< 0.0001
A	12/121 (9.9)	28/147 (19.1)
B	18/121 (14.9)	54/147 (36.7)
C	90/121 (74.4)	62/147 (42.2)
Baseline HBV-DNA level (mean ± SD, copies/mL)	6.7 ± 1.6 Log₁₀	7.3 ± 1.9 Log₁₀	0.003
PC¹ 1896 mutant, n (%)			0.8
Yes	35/124 (28.2)	46/156 (29.5)
No	89/124 (71.8)	110/156 (70.5)
HBeAg, n (%)			0.07
+	68/124 (54.8)	101/154 (65.6)
−	56/124 (45.2)	53/154 (34.4)

¹Precore.

Citation: Tong MJ, Blatt LM, Kao JH, Cheng JT, Corey WG. Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma. World J Gastroenterol 2006; 12(41): 6620-6626
URL: https://www.wjgnet.com/1007-9327/full/v12/i41/6620.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i41.6620