Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis

Figure 4 Marker genes for hematopoietic cells in the Kupffer cell fraction. Expression profi les of the whole liver and the isolated Kupffer cell fraction during fi brogenesis were obtained using a rat genome U34A array (Affymetrix). Marker genes for hematopoietic cells in the Kupffer cell fraction are listed. Expression intensities are given for d 0, and expression intensity data for d 4, 7,14, 21 and 28 are shown as ratios to the d 0 expression data for analysis of hematopoietic cells in whole liver. The classifi cation of genes into groups 1-4 and corresponds to the maximum change of expression at the different time points on d 7, 14, 21, 28 and 4, respectively. Italicized values indicate an “absent” call by the Affymetrix software. The bold values indicate the highest or lowest ratio in the chronic phase (d 7, 14, 21 and 28). Cell types in the infl ammatory cell fraction are as follows: M: Monocytes and their progenitors; L: Lymphocytes and their progenitors; E: Erythrocytes and their progenitors; P: Platelets and their progenitors; Leu: Other kinds of leukocytes and their progenitors.