Peroxisome proliferator-activated receptor γ agonist reduces the severity of post-ERCP pancreatitis in rats

Figure 6 NFκB activation. A: NFκB DNA binding activity of pancreas nuclear extracts expressed as % of control p65 activity. Post-ERCP induced pancreatitis resulted in increased levels of p65 binding activity. This increase was inhibited by rosiglitazone pre-treatment. ^aP < 0.05 AP vs Control; ^cP < 0.05 rosiglitazone-treated AP group vs vehicle-treated AP group; B: Western blot of nuclear p65 confirmed the nuclear translocation of p65 protein during ERCP-induced pancreatitis. This nuclear translocation was not observed after rosiglitazone administration. Western blot was representative of three different experiments.