Peroxisome proliferator-activated receptor γ agonist reduces the severity of post-ERCP pancreatitis in rats

Figure 4 Histological examination of the pancreas (x 200). A: Control pancreas showed normal acinar structure; B: No morphological changes were observed after rosiglitazone administration in control animals; C: Experimental ERCP-induced pancreatic damage reflected in interlobular and interacinar edema and areas of leukocyte infiltration (arrows). Acinar necrosis was not observed; D: Rosiglitazone pre-treatment before contrast medium infusion resulted in a reduced edema and absence of leukocyte cell infiltration.