Peroxisome proliferator-activated receptor γ agonist reduces the severity of post-ERCP pancreatitis in rats

Figure 2 PPARγ activation. A: PPARγ DNA binding activity of pancreas nuclear extracts expressed as % of control activity. No significant differences were observed on PPARγ binding to DNA after pancreatitis induction. By contrast, PPARγ binding to DNA is strongly induced by rosiglitazone in both control and pancreatitis groups. ^aP < 0.05 Rosiglitazone-treated vs vehicle-treated groups. B: Western blot of nuclear PPARγ confirmed the nuclear translocation of PPARγ protein after rosiglitazone administration in both control and pancreatitis groups. Western blot was representative of three different experiments.