Nitric oxide synthase and heme oxygenase expressions in human liver cirrhosis

Figure 4 Immunohistochemistry of cirrhotic livers sections (left panel) and non-cirrhotic sections(right panel). A and B, show no difference in nNOS localization; likewise with iNOS as shown in C and D. eNOS was found to have translocated mainly to the nuclei in cirrhotic sections as evidenced in E, but found in hepatocyte cytoplasm and endothelial cells in non-cirrthotic as in F. In G and H, HO-1 is clearly found in macrophages with marked increase in cirrhotic sections (G). HO-2 was more highly expressed in the cytoplasm of hepatocytes in cirrhotic (I) than non-cirrhotic (J) tissues. Cirrhotic liver in K shows higher immunoreactivity to caveolin-1 that that of non-cirrhotic liver in L. In all IHC, monoclonal antobodies were used.