Cytotoxic T-lymphocyte antigen 4 gene polymorphisms and susceptibility to chronic hepatitis B

Table 1 Distribution of allele and genotype frequency of CTLA-4 +49, -318, -1172 polymorphisms in hepatitis B patients and controls

	Chronic hepatitis B n (%)	Controlsn (%)
+49 genotype frequency (P = 0.211)
G+A–	9 (17.6)	41 (27.3)
G+A+	16 (31.4)	52 (34.7)
G–A+	26 (51)	57 (38)
+49 allele frequency
G+	25 (49)	93 (62)
A+	42 (82.4)	109 (72.7)
–318 genotype frequency (P = 0.012)
T+C–	0 (0)	6 (4)
T+C+	10 (19.6)	10 (6.7)
T–C+	41 (80.4)	134 (89.3)
–318 allele frequency
T+	10 (19.6)	16 (10.7)
C+	51 (100)	44 (96)
–1172 genotype frequency (P = 0.061)
T+C–	36 (70.6)	108 (72)
T+C+	13 (25.5)	42 (28)
T–C+	2 (3.9)	0 (0)
–1172 allele frequency
C+	15 (29.4)	42 (28)
T+	49 (96.1)	150 (100)