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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 28, 2006; 12(4): 615-620
Published online Jan 28, 2006. doi: 10.3748/wjg.v12.i4.615
Published online Jan 28, 2006. doi: 10.3748/wjg.v12.i4.615
Table 4 Phenotypic among UC patients classified as carriers or non-carriers of mutations at the HNMT gene
| Phenotypic characteristics | Carriersn = 34 | Non-carriersn = 161 | OR (95% CI)p value |
| Male:Female | 20:14 | 91:70 | 1.10 (0.49-2.49) 0.81 |
| Mean age at diagnosis, yr (range) | 35 (6-83) | 38 (17-81) | P = 0.24 |
| Mean duration of disease, yr (range) | 12.4 (2-39) | 11.3 (2-41) | P = 0.11 |
| Family history of IBD, n (%) | 8 (23.5%) | 35 (21.7%) | 1.11 (0.42-2.85) 0.82 |
| Smokers at diagnosis, n (%) | 8 (23.5%) | 31 (19.3%) | 1.29 (0.48-3.36) 0.57 |
| Previous appendectomy, n (%) | 2 (5.9%) | 6 (3.7%) | 1.61 (0.21-9.47) 0.63 |
| Previous tonsillectomy, n (%) | 2 (5.9%) | 17 (10.5%) | 0.53 (0.08-2.57) 0.54 |
| Extent of UC | |||
| Extensive, n (%) | 15 (44.1%) | 64 (39.8%) | 1.20 (0.53-2.69) 0.63 |
| Non-extensive, n (%) | 19 (55.9%) | 97 (60.2%) | |
| Extraintestinal manifestations | |||
| Cutaneous, n (%)) | 6 (17.6%) | 19 (11.8%) | 1.60 (0.52-4.66) 0.4 |
| Articular, n (%) | 15 (44.1%) | 47 (29.2%) | 1.91 (0.84-4.35) 0.09 |
| Ocular, n (%) | 1 (2.9%) | 5 (3.1%) | 0.95 (0.02-8.86) 1 |
| Hepatic, n (%) | 5 (14.7%) | 27 (16.8%) | 0.86 (0.26-2.60) 0.77 |
| Therapy categories | |||
| Immunosuppressants, n (%) | 8 (23.5%) | 37 (23%) | 1.031 (0.39-2.65) P = 0.94 |
| Surgery, n (%) | 6 (17.6%) | 16 (9.94%) | 1.941 (0.62-5.91) 0.20 |
- Citation: García-Martín E, Mendoza JL, Martínez C, Taxonera C, Urcelay E, Ladero JM, Concha EGL, Díaz-Rubio M, Agúndez JA. Severity of ulcerative colitis is associated with a polymorphism at diamine oxidase gene but not at histamine N-methyltransferase gene. World J Gastroenterol 2006; 12(4): 615-620
- URL: https://www.wjgnet.com/1007-9327/full/v12/i4/615.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i4.615