Role of gastric oxidative stress and nitric oxide in formation of hemorrhagic erosion in rats with ischemic brain

Table 3 Effect of L-NAME on L-arginine produced amelioration of various gastric biomedical parameters in sham operation and BCAL rats

	mg/kg	Acid back-diffusion(μEq/stomach)	Glutathione(μmol/g tissue)	Lipid peroxides(nmol MDA/g tissue)	Histamine(μg/g stomach)	Hemoglobin(mg/stomach)	Erosionarea (mm2)
Sham operation
Vehicle		-125.2 ± 4.4	2.6 ± 0.3	48.1 ± 3.4	52.8 ± 4.6	0.1 ± 0.1	3.2 ± 0.7
L-arginine	500	-96.0 ± 6.0a	3.5 ± 0.4a	36.1 ± 4.5a	38.2 ± 3.6a	0 ± 0a	0.3 ± 0.2a
L-NAME25
+ L-arginine	500	-156.0 ± 11.0ac	2.3 ± 0.2c	60.1 ± 4.5ac	72.4 ± 6.3ac	0.7 ± 0.1ac	12.0 ± 3.5ac
BCAL
Vehicle		-245.2 ± 14.4	1.6 ± 0.2	127.8 ± 9.3	110.4 ± 9.8	1.6 ±  0.3	36.2 ± 5.1
L-arginine
	25	-216.1 ± 9.6a	2.0 ± 0.2	80.8 ± 7.8a	98.7 ± 10.4	1.3 ± 0.2	28.2 ± 5.4
	250	-189.4 ± 3.6a	2.3 ± 0.3a	66.7 ± 4.4a	84.3 ± 7.4a	1.0 ± 0.1a	20.0 ± 4.8a
	500	-144.0 ± 11.0a	2.6 ± 0.2a	46.1 ± 8.5a	54.1 ± 8.6a	0.7 ± 0.1a	12.0 ± 3.5a
L-NAME	25
+ L-arginine	500	-287.6 ± 16.4ac	1.2 ± 0.2ac	157.6 ± 11.3ac	110.4 ± 9.8ac	2.8 ± 0.3ac	56.2 ± 6.0ac

Data are means±SE (N = 6).

^aP < 0.05 vs corresponding vehicle.

^cP< 0.05 vs corresponding arginine treatment (500 mg/kg) of BCAL group. MDA= malonedialdehyde, BCAL= bilateral carotid artery ligation, L-NAME= NG-nitro-L-arginine-methyl ester.